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Tamiflu® (oseltamivir phosphate) is an antiviral medicine for treatment of flu in people 2 weeks of age and older and for prevention of flu in people 1 year of age and older. See full safety for more information. Key takeaways: Antiviral prescription flu medicines, such as Tamiflu (oseltamivir), Xofluza (baloxavir marboxil), and Relenza (zanamivir), can shorten the duration and severity of the flu. Over-the-counter (OTC) medicines for influenza mainly treat symptoms. It's best to pick an OTC flu medicine based on your symptoms. 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